{"id":11476,"date":"2025-07-31T19:10:25","date_gmt":"2025-07-31T10:10:25","guid":{"rendered":"http:\/\/cosmekitchenwp.win-win.partners\/article\/?p=11476"},"modified":"2025-08-01T10:27:15","modified_gmt":"2025-08-01T01:27:15","slug":"04_photoaging","status":"publish","type":"post","link":"http:\/\/cosmekitchenwp.win-win.partners\/article\/antiaging_katsuta\/04_photoaging\/","title":{"rendered":"\u3010\u7b2c\u56db\u56de\u3011\u304a\u808c\u306e\u8001\u5316\u539f\u56e0\u306e80\uff05\u3067\u3042\u308b\u300c\u5149\u8001\u5316\u300d\u306b\u30b5\u30e8\u30ca\u30e9\u3059\u308b\uff01"},"content":{"rendered":"\n<p 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class=\"wp-block-image size-full\"><img decoding=\"async\" src=\"https:\/\/cosmekitchenwp.win-win.partners\/article\/wp-content\/uploads\/2025\/07\/cbf5b9f60da99bf791c0aa12a770f429.jpg\" alt=\"\" class=\"wp-image-11675\"\/><\/figure>\n\n\n\n<p>\u79c1\u305f\u3061\u306e\u76ee\u306b\u8272\u3068\u3057\u3066\u898b\u3048\u308b\u300c\u53ef\u8996\u5149\u7dda\u300d\u306b\u306f\u3001\u7d2b\u3001\u9752\u3001\u7dd1\u3001\u9ec4\u3001\u6a59\u3001\u8d64\u306a\u3069\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u305d\u306e\u4e2d\u306e\u9752\u3044\u5149\u300c\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u300d\u306f\u3001\u808c\u306b\u65e5\u713c\u3051\u3092\u8d77\u3053\u3059\u3053\u3068\u3053\u305d\u3001\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u304c\u53ef\u8996\u5149\u7dda\u306e\u4e2d\u3067\u306f\u7d2b\u5916\u7dda\u306b\u6b21\u3044\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u304c\u5f37\u304f\u3001\u3057\u304b\u3082\u771f\u76ae\u307e\u3067\u5dee\u3057\u8fbc\u3093\u3067\u3044\u308b\u9577\u3044\u6ce2\u9577\u306a\u306e\u3067\u3001\u3053\u308c\u307e\u305f\u9577\u671f\u7684\u306b\u898b\u308b\u3068\u5149\u8001\u5316\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u306f\u592a\u967d\u5149\u3060\u3051\u3067\u306a\u304f\u30b9\u30de\u30db\u3084PC\u306eLED\u30d0\u30c3\u30af\u30e9\u30a4\u30c8\u306b\u3082\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u9854\u306b\u3068\u3066\u3082\u8fd1\u3044\u4f4d\u7f6e\u3067\u56db\u516d\u6642\u4e2d\u304a\u808c\u306b\u5dee\u3057\u8fbc\u3093\u3067\u3044\u308b\u73fe\u4ee3\u793e\u4f1a\u306f\u7531\u3005\u3057\u304d\u4e8b\u614b\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u306f\u5e74\u9f62\u304c\u82e5\u304f\u3066\u3082\u540c\u3058\u3067\u3001\u65b0\u9673\u4ee3\u8b1d\u304c\u6bd4\u8f03\u7684\u65e9\u3044\u304b\u3089\u30c0\u30e1\u30fc\u30b8\u304c\u4eca\u306e\u3068\u3053\u308d\u76ee\u7acb\u3061\u306b\u304f\u3044\u3060\u3051\u3067\u3001\u3053\u3046\u3057\u305f\u5149\u306b\u3088\u308b\u808c\u3078\u306e\u5f71\u97ff\u306f\u300c\u84c4\u7a4d\u578b\u306e\u30c0\u30e1\u30fc\u30b8\u300d\u3067\u3042\u308b\u3053\u3068\u306f\u809d\u306b\u9298\u3058\u3066\u304a\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n<h2 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class=\"wp-image-11676\"\/><\/figure>\n\n\n\n<p>\u79c1\u304c\u5149\u8001\u5316\u3092\u9632\u3050\u305f\u3081\u306b\u3084\u3063\u3066\u3044\u308b\u3053\u3068\u306f\u3044\u308d\u3044\u308d\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u307e\u305a\u7d2b\u5916\u7dda\u91cf\u306e\u591a\u304410\u6642\u304b\u308914\u6642\u306b\u5916\u51fa\u3059\u308b\u6642\u306f\u3001\u30c4\u30d0\u304c\u300c10cm\u4ee5\u4e0a\u300d\u306e\u5e3d\u5b50\u3092\u304b\u3076\u308b\u3053\u3068\u3002\u590f\u306f\u3053\u306e\u6642\u9593\u5e2f\u4ee5\u5916\u3067\u3082\u5e38\u306b\u30ad\u30e3\u30c3\u30d7\u3092\u304b\u3076\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u3046\u3059\u308b\u3068\u3053\u308c\u3060\u3051\u3067\u3001\u5b9f\u306f\u9854\u306e70\uff05\u306f\u30ab\u30d0\u30fc\u51fa\u6765\u3061\u3083\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>70\uff05\u3068\u3044\u3046\u306e\u306f\u3001\u304b\u306a\u308a\u5f71\u97ff\u304c\u5927\u304d\u304f\u306a\u3044\u3067\u3059\u304b\uff1f\u3082\u3061\u308d\u3093\u305d\u308c\u4ee5\u5916\u306b\u3082\u3001\u6625\u590f\u306f\u65e5\u5098\u3084\u30b5\u30f3\u30b0\u30e9\u30b9\u306a\u3069\u3082\u30ab\u30d0\u30f3\u306b\u5e38\u5099\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3082\u3046\uff11\u3064\u306f\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u3001\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30d3\u30bf\u30df\u30f3E\u306e\u591a\u3044\u98df\u3079\u7269\u3092\u98df\u3079\u305f\u308a\u3001\u808c\u306b\u5857\u3063\u305f\u308a\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n<p>21\u6b73\uff5e59\u6b73\u306e\u5973\u602766\u540d\u306e\u808c\u306e\u5199\u771f\u3092\u64ae\u308a\u3001\u305d\u306e\u4e2d\u304b\u308930\u4ee3\u306850\u4ee3\u304b\u3089\u305d\u308c\u305e\u308c4\u540d\u3001\u808c\u306e\u7f8e\u3057\u3044\u65b9\u3068\u666e\u901a\u306e\u65b9\u3092\u9078\u3073\u3001\u305d\u306e\u65b9\u3005\u306e\u89d2\u8cea\u5c64\u306e\u4e2d\u306e\u9175\u7d20\u6d3b\u6027\u3092\u8abf\u3079\u308b\u3068\u8a00\u3046\u3001\u5b9f\u306b\u8208\u5473\u6df1\u3044\u5b9f\u9a13\u30c7\u30fc\u30bf\u3092\u898b\u305f\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3059\u308b\u3068\u3001\u898b\u305f\u76ee\u304c\u7f8e\u3057\u3044\u808c\u306e\u65b9\u306f\u3001\u3059\u3079\u3066\u306b\u304a\u3044\u3066\u89d2\u8cea\u5185\u306e\u9175\u7d20\u6d3b\u6027\u304c\u9ad8\u304b\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u306e\u9175\u7d20\u306f\u4f55\u304b\u3068\u3044\u3046\u3068\u3001\u4e0d\u8981\u306a\u89d2\u8cea\u3092\u5265\u304c\u308c\u3084\u3059\u304f\u3059\u308b\u9175\u7d20\u3084\u3001\u6f64\u3044\u7269\u8ceaNMF\u3092\u7523\u751f\u3059\u308b\u9175\u7d20\u3001\u305d\u3057\u3066\u6ce8\u76ee\u3059\u3079\u304d\u306f\u6d3b\u6027\u9178\u7d20\u3092\u7121\u5bb3\u5316\u3059\u308bSOD\u9175\u7d20\u3084\u30ab\u30bf\u30e9\u30fc\u30bc\u9175\u7d20\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3046\u3044\u3046\u9175\u7d20\u6d3b\u6027\u306f\u3001\u907a\u4f1d\u7684\u306a\u9762\u304c\u5927\u304d\u3044\u306e\u3067\u3057\u3087\u3046\u3051\u3069\u3001\u79c1\u306f\u3053\u306e\u5b9f\u9a13\u7d50\u679c\u3092\u898b\u3066\u9006\u306b\u5e0c\u671b\u3092\u6301\u3061\u307e\u3057\u305f\u3002\u3060\u3063\u3066\u771f\u76ae\u3067\u306f\u306a\u304f\u8868\u76ae\u3001\u3057\u304b\u3082\u4e00\u756a\u4e0a\u306e\u89d2\u8cea\u5c64\u306e\u9175\u7d20\u6d3b\u6027\u3060\u3063\u305f\u304b\u3089\u3067\u3059\u3002\u89d2\u8cea\u3067\u306e\u6d3b\u6027\u9178\u7d20\u51e6\u7406\u306a\u3069\u3067\u304a\u808c\u306e\u7f8e\u3057\u3055\u304c\u5909\u308f\u308b\u306e\u3067\u3059\u304b\u3089\u3001\u81ea\u5206\u306e\u81ea\u524d\u306e\u9175\u7d20\u6d3b\u6027\u304c\u30a4\u30de\u30a4\u30c1\u306a\u3089\u3001\u690d\u7269\u306e\u529b\u3092\u501f\u308a\u308c\u3070\u3044\u3044\u3068\u601d\u3046\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3060\u3063\u3066\u89d2\u8cea\u306f\u3001\u308f\u305a\u304b0.02mm\u3002\u808c\u306e\u4e00\u756a\u4e0a\u3067\u3059\u3088\u3002\u305d\u3093\u306a\u306b\u6df1\u304f\u6d78\u900f\u3059\u308b\u5fc5\u8981\u3082\u306a\u3044\u308f\u3051\u3067\u3059\u3002\u690d\u7269\u306e\u30d5\u30a3\u30c8\u30b1\u30df\u30ab\u30eb\u3092\u808c\u306b\u7e8f\u3048\u3070\u3044\u3044\uff01<\/p>\n\n\n\n<p>\u4e00\u91cd\u9805\u9178\u7d20\u306a\u3069\u306e\u76ae\u819a\u306b\u5bb3\u3092\u3082\u305f\u3089\u3059\u6d3b\u6027\u9178\u7d20\u3092\u7121\u5bb3\u5316\u3059\u308b\u6210\u5206\u304c\u3001\u690d\u7269\u306e\u4e2d\u306b\u767a\u898b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3\u3001\u03b2\u30ab\u30ed\u30c6\u30f3\u3001\u30eb\u30c6\u30a4\u30f3\u3001\u30ea\u30b3\u30d4\u30f3\u306a\u3069\u306e\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u3084\u30d7\u30ed\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30b8\u30f3\u3001\u30b1\u30eb\u30bb\u30c1\u30f3\u3001\u30a8\u30e9\u30b0\u9178\u306a\u3069\u306e\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u3001\u30d3\u30bf\u30df\u30f3E\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e2d\u3067\u3082\u3001\u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3\u306e\u6301\u3064\u529b\u306f\u3059\u3054\u3044\u3067\u3059\u3002\u30a2\u30b9\u30bf\u30ad\u30b5\u30f3\u30c1\u30f3\u306f\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mg\u306e\u03b2-\u30ab\u30ed\u30c6\u30f3\u30012.2 mg \u306e\u30eb\u30c6\u30a4\u30f3\u30010.7 mg\u306e\u30bc\u30a2\u30ad\u30b5\u30f3\u30c1\u30f3\u304a\u3088\u3073\u30010.4 mg\u306e\u30ea\u30b3\u30d4\u30f3\u3092\u542b\u3080\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3055\u308c\u305f22\u624d\uff5e66\u624d24\u4eba\u306e\u5065\u5eb7\u306a\u88ab\u9a13\u8005\u306e\u76ae\u819a\u3068\u76ae\u819a\u8102\u8cea\u306e\u6d3b\u6027\u9178\u7d20\u4fdd\u8b77\u306e\u69d8\u5b50\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u3092\u6442\u53d6\u3057\u3066\u3044\u308b\u7fa4\u3067\u3001\u512a\u4f4d\u306b\u76ae\u819a\u306e\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u6fc3\u5ea6\u304c\u4e0a\u6607\u3057\u3001\u76ae\u819a\u306b\u304a\u3051\u308b\u6d3b\u6027\u9178\u7d20\u9664\u53bb\u6d3b\u6027\u304c\u9ad8\u307e\u3063\u305f\u305d\u3046\u3067\u3059\u3002 \u3053\u306e\u7814\u7a76\u4ee5\u5916\u3067\u3082\u9069\u5207\u306a\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u306e\u6295\u4e0e\u304c\u7d2b\u5916\u7dda\u306b\u5bfe\u3059\u308b\u5149\u9632\u8b77\u3001\u76ae\u819a\u8001\u5316\u306e\u52a0\u901f\u9632\u6b62\u306b\u306a\u308b\u3068\u3044\u3046\u7814\u7a76\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u8ad6\u6587\uff1aMeinke M. C. et al. \u76ae\u819a\u3068\u76ae\u819a\u8102\u8cea\u306e\u30e9\u30b8\u30ab\u30eb\u9664\u53bb\u80fd\u529b\u3078\u306e\u98df\u7269\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u306e\u5f71\u97ff\u3002\u300cEuropean Journal of Pharmaceutics and Biopharmaceutics. 2013; 84(2):365-373\u300d<\/p>\n<\/blockquote>\n\n\n\n<p>\u03b2\u30ab\u30ed\u30c6\u30f3\u306f\u306b\u3093\u3058\u3093\u3001\u304b\u307c\u3061\u3083\u3001\u307b\u3046\u308c\u3093\u8349\u3001\u30e2\u30ed\u30d8\u30a4\u30e4\u3001\u6625\u83ca\u3001\u30cb\u30e9\u306a\u3069\u3001\u30eb\u30c6\u30a4\u30f3\u306f\u3001\u307b\u3046\u308c\u3093\u8349\u3001\u304b\u307c\u3061\u3083\u3001\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u3001\u30b1\u30fc\u30eb\u3001\u30de\u30ea\u30fc\u30b4\u30fc\u30eb\u30c9\u3001\u30bc\u30a2\u30ad\u30b5\u30f3\u30c1\u30f3\u306f\u304b\u307c\u3061\u3083\u3001\u30d6\u30ed\u30c3\u30b3\u30ea\u30fc\u3001\u3068\u3046\u3082\u308d\u3053\u3057\u3001\u30aa\u30ec\u30f3\u30b8\u3001\u30de\u30f3\u30b4\u30fc\u3001\u6843\u306a\u3069\u3001\u30ea\u30b3\u30d4\u30f3\u306f\u30c8\u30de\u30c8\u3001\u30b9\u30a4\u30ab\u3001\u67ff\u306a\u3069\u306b\u591a\u3044\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u6625\u590f\u306f\u610f\u8b58\u3057\u3066\u3053\u3046\u3057\u305f\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u3092\u6442\u3063\u3066\u304a\u304f\u3068\u826f\u3044\u3068\u601d\u3044\u307e\u3059\uff01<\/p>\n\n\n\n<h2 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